This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types.
The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers.
Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
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분야별 서적
Essential Bioimaging Methods
Animal Models for Development of Cancer Immunotherapy
Cancer Biomarkers: Clinical Aspects and Laboratory Determination
Immunoinformatics of Cancers: Practical Machine Learning Approaches Using R 1st Edition 
Clinical Applications of Noncoding RNAs in Cancer 
Cancer Biology: How Science Works
Prognostic and Therapeutic Applications of RKIP in Cancer 
Biomarkers in Cancer Therapy: Liquid Biopsy Comes of Age
Immunotherapy of Cancer (Advances in Cancer Research 143) 
Precision Medicine in Cancer Therapy (Cancer Treatment and Research 178) 
