Presents clinical syndromes associated with small- and large-vessel pathology encountered in the autoimmune connective tissue disorders. Covers the pathogenesis, clinical implications, and treatment of these diseases, and addresses current therapies available for treatment, such as fibrinolytic treatments, prostacycline derivatives, and anti- platelet compounds. Includes a separate chapter devoted to the use of long-term anticoagulation and the newer low-molecular weight heparins. Some specific topics include markers of endothelial damage, vascular manifestations in necrotizing and granulomatous vasculitides, and pharmacological treatment for thrombotic diseases. Asherson is affiliated with the Rheumatic Disease Unit at Groote Schuur Hospital, University of Cape Town, South Africa.Book News, Inc.? Portland, OR
Book Description Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease.
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