The book provides a broad overview of the current "state-of-the-art" in the use of chemotherapy for primary and metastatic brain tumors and includes information on traditional (e.g., alkylating agents, spindle poisons, topoisomerase inhibitors, etc) and non-traditional (e.g., intra-arterial approaches, blood-brain barrier disruption, etc) forms of chemotherapy. In addition, newer molecular-based chemotherapeutic agents (e.g., tyrosine kinase inhibitors, ras pathway inhibitors, PI3 kinase inhibitors, mTOR inhibitors, angiogenesis inhibitors, etc) are included. Well-founded in basic science and pharmacology, the chapters provide an overview of relevant background material in critical areas such as drug pharmacology and mechanisms of action, molecular biology (e.g., critical oncogenes, tumor suppressor genes), signal transduction pathways, angiogenesis pathways, and developmental pharmacology.
From the Back Cover
Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including targeted agents. In Handbook of Brain Tumor Chemotherapy, Dr. Herbert Newton and a distinguished panel of experts in the field of neuro-oncology and brain tumor therapy, review the state of the art of chemotherapy development and clinical treatment of patients with this devastating disease. The Handbook is comprehensive in scope and contains 35 chapters, divided into four sections: Section I covers the basic pharmacology and clinical applications of brain tumor chemotherapy; Section II reviews the molecular biology and basic science of brain tumors, with a focus on the development and clinical application of molecular, targeted therapeutic agents; Section III reviews innovative approaches to brain tumor chemotherapy delivery; and Section IV which provides a detailed review of chemotherapy for each of the major brain tumor types.
Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.
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