This volume provides a unifying conceptual framework for the genomic control system that encodes development of the body plan. The authors have dealt with a range of formerly disparate fields to create a synthesis refracted through the lens of gene regulatory networks (GRNs). In this book, without immersing the reader in descriptive details, selected recent results from a great variety of animal model systems are embedded in a conceptual resolution of the control logic underlying the developmental process, and of the changes in that logic by which evolution of the body plan occurs. Both the breadth of the biological processes treated, and the framework conceptual approach makes this an entirely unique work. It is intended for biologists and molecular biologists, with or without expertise in development or evolution per se, but it will also provide illumination for engineers, physicists, mathematicians, for students of any of these fields, and for anyone who feels the requirement to organize their understanding of development or evolution as the output of genomic control processes.
The book begins with a consideration of the relative roles of the different levels of control affecting developmental gene expression in animal cells, an overview of the physical nature of the regulatory genome, and the fundamental experimental demonstration of its primacy. The second Chapter provides an in depth understanding of GRNs, of how they generate the regulatory conditions that control all else, of the significance of the cis-regulatory functions operating at the network nodes, of the dynamics of transcriptional activity, and of the Boolean spatial patterns that GRNs output in development. The following three Chapters apply network theory to three different kinds of developmental process: to embryonic development of all major kinds; to development of adult body parts and organs; and to cell fate specification. Chapter 6 examines the conceptual richness that has derived from various approaches to predictive, quantitative models of GRNs and GRN circuits. In the final section of this book much of the foregoing is applied to the conceptual problems of understanding bilaterian evolution, including the underlying explanation of hierarchical animal phylogeny, the flexibility or inflexibility of different aspects of GRNs to evolutionary change, and the discontinuity of evolutionary rates of change, and of how productive evolution of GRNs does and does not occur. The outcome is a set of keys that unlock the apparent mysteries of large aspects of bilaterian evolution.
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